1Si Ahmed Hakim, 1Ouardia Belarbi, 1Smail Daoudi, 1Ferroudja Miloudi, 1Massinissa Lounis

1Department of Neurology, Nedir Mohamed Teaching Hospital, Tizi Ouzou, Algeria


The goal is to think about leukodystrophy which can mimic a progressive picture of multiple sclerosis

Material(s) and Method(s):

We report the observation of a man with adreno-leukodystrophy whose neurological manifestations were late.


The diagnosis of adrenoleukodystrophy is made on a bundle of clinical and radiological arguments (male, presence of adrenal damage, appearance of radiological lesions, encephalic and medullary damage), the diagnosis is confirmed by the determination of very long chain fatty acids.


Adrenoleukodytrophy can mimic certain pathologies, in particular multiple sclerosis in its progressive form, hence the interest of certain paraclinical examinations and a good analysis of the imagery.

Lorenzo’s oil normalizes C26 levels within 4 weeks but has no effect on neurological progression patients already affected. However, this therapeutic management seems to be interesting in patients asymptomatic and not having cerebral involvement.